JPMorgan Chase & Co. plans to allow institutional clients to use their holdings of Bitcoin and Ether as collateral for loans by the end of the year in a significant deepening of Wall Street’s crypto integration.

The program, offered globally, will rely on a third-party custodian to safeguard the pledged tokens, according to people familiar with the matter. It builds on JPMorgan’s earlier move to accept crypto-linked ETFs as collateral.