Rosie O’Donnell tore apart Jeff Bezos and his “fake fembot wife,” Lauren Sánchez, for their over-the-top $50 million wedding in Venice, Italy.

“The BEZOS wedding,” the comedian wrote via Instagram Monday, along with alleged photos of the former journalist’s appearance before and after cosmetic work.

O’Donnell called out the “billionaires” who gathered for the nuptials “in the gross excess of it all” — adding that it “turned [her] stomach.”

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“Is Oprah friends with Jeff Besos [sic] really — how is that possible,” the “View” alum, 63, continued.

O’Donnell claimed the Amazon founder “treats his employees with disdain” and that “by any metric he is not a nice man.”

She then called out Sánchez, saying, “And his fake fem bot [sic] wife who looks like that. Why would he choose her after the salt of the earth Mackenzie.”

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The “League of Their Own” star was referring to Bezos’ first wife, MacKenzie Scott, whom he was married to from 1993 to 2019.

“Sold his soul is what it looks like from here. The devil is smiling at all his conquests,” O’Donnell concluded.

Reps for Bezos, 61, and Sánchez, 55, were not immediately available to Page Six for comment.

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Social media users in O’Donnell’s comments section were divided over her harsh commentary about the newlyweds.

“We’ve lost touch completely. With what’s real, with what matters, with each other,” one person agreed.

“All those members of the arts … it’s disappointing, really,” another added.

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“I was shocked to see Leonardo DiCaprio there … Mr Climate change himself partying with one of the most destroyed people on the planet,” a third chimed in.

But Robin Thicke’s wife, April Love Geary, was one of many to chide O’Donnell, writing, “I’m not a fan of them — but I don’t think it’s a good look to make fun of other people’s appearances.

“I’m all for disliking people because of how they treat others/etc but it is sad to see women post overly edited pictures of women and talk poorly about their appearances so publicly.”

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“Can’t we just stick to talking about how Bezos treats his employees terribly? Why do we have to tear women’s looks apart on social media,” Geary continued.

“This is called bullying … so sad … it’s sad to see women bullying other women,” another person echoed.

Bezos and Sánchez were also shaded by Charlize Theron, who said “they suck” while speaking at a charity event over the weekend.

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The couple invited A-list guests, including the Kardashians, Orlando Bloom and Sydney Sweeney, to their extravagant three-day wedding celebration, which began with a welcome party on Thursday evening.

They then tied the knot on San Giorgio Maggiore island Friday and hosted a pajama-themed party the following night.

The weekend came to a close as several celebrities were spotted leaving for the airport on Sunday.