Soleno Therapeutics (SLNO): Does Current Valuation Signal Opportunity or Caution for Inves
November 30, 2025
Soleno Therapeutics (SLNO) has seen its stock price swing in recent weeks, catching the attention of investors looking for value and momentum. The company focuses on treatments for rare diseases, which often draws keen interest from the biotech community.
See our latest analysis for Soleno Therapeutics.
Soleno’s share price has been on a volatile run lately, with strong short-term swings: up nearly 12% for the week, but still down around 25% over the past three months. Despite recent turbulence, the company’s long-term performance truly stands out, with a staggering 4,846% total shareholder return over three years and a remarkable 74% over five years. This highlights the potential for biotech momentum to accelerate quickly as sentiment shifts.
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Given such explosive historical returns but steep recent drops, is Soleno Therapeutics now flying under the radar at a bargain price, or is the market already factoring in all the company’s future growth prospects?
With its current price-to-sales ratio standing at 27.5x, Soleno Therapeutics trades at a hefty premium versus peers. This suggests the market is pricing in significant future growth.
The price-to-sales (P/S) ratio measures the value investors are placing on each dollar of the company’s sales and is commonly used for companies that do not yet generate profits, like many in the biotech sector. A higher ratio can indicate robust growth expectations, but it also suggests the stock price could be vulnerable if those expectations are not met.
In Soleno’s case, the P/S ratio is well above both the U.S. biotech industry average of 12.8x and the peer average of 22.5x. This signals investors see Soleno’s future as much brighter than its competitors. However, it is also trading above the estimated fair price-to-sales ratio of 21.4x, a level the market could recalibrate toward if growth stumbles.
Explore the SWS fair ratio for Soleno Therapeutics
Result: Price-to-Sales of 27.5x (OVERVALUED)
However, strong revenue growth alone cannot guarantee future gains. Setbacks in clinical trials or regulatory challenges could swiftly reverse positive sentiment.
Find out about the key risks to this Soleno Therapeutics narrative.
While Soleno’s price-to-sales ratio appears steep, our DCF model presents a different perspective. Based on projected future cash flows, the SWS DCF model estimates the fair value at $431.02, making the current share price of $50.45 appear significantly undervalued. The question remains whether the market is underestimating Soleno’s potential or if risks continue to outweigh the possible rewards.
Look into how the SWS DCF model arrives at its fair value.
Simply Wall St performs a discounted cash flow (DCF) on every stock in the world every day (check out Soleno Therapeutics for example). We show the entire calculation in full. You can track the result in your watchlist or portfolio and be alerted when this changes, or use our stock screener to discover 914 undervalued stocks based on their cash flows. If you save a screener we even alert you when new companies match – so you never miss a potential opportunity.
If you have your own perspective or want to follow your research instincts, it’s easy to assemble your own view in just a few minutes. Do it your way
A great starting point for your Soleno Therapeutics research is our analysis highlighting 3 key rewards and 2 important warning signs that could impact your investment decision.
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This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.
Companies discussed in this article include SLNO.
Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team@simplywallst.com
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